In-Silico Study Of Bioactive Compounds In Bawang Dayak (Eleutherine palmifolia (L) Merr.) Bulbs On The Main Protease Receptor Of COVID-19 (6LU7) As A Candidate For SARS-CoV-2 Antivirus Drug
DOI:
https://doi.org/10.36858/jmid.v3i2.40Keywords:
Antivirus, COVID-19, Eleutherine palmifolia, Molecular docking, SARS-CoV-2Abstract
: The COVID-19 viral disease is a new name given by the World Health Organization (WHO) to patients with the novel COVID-19 virus infection which was first reported from the city of Wuhan, China at the end of 2019. The COVID-19 pandemic is still a major problem in the world health. One antiviral regimen that is widely used to treat moderate to severe Covid- 19 patients is favipiravir. Many studies discuss alternative antiviral therapy for COVID-19 patients from active compounds contained in plants. One of the medicinal plants that has an antiviral effect on CoV-2 is Dayak onion (Eleutherine Palmifolia (L.) Merr). Consuming herbal plants can increase the body's immunity as the main key in preventing the Sars-Cov-2 virus.
Purpose: This research aims to determine the effect of anchoring the active compound of Dayak onion bulbs on the growth of the corona virus on the main protease receptor for Covid 19 (6LU7).
Methods: This type of research uses a molecular docking research method which consists of docking validation stages, a docking process and continues with docking visualization using Discovery Studio Visualizer and PyRx combined with Autodocktool
Results: The results of the molecular docking simulation show that the Lysine sulfate compound has the lowest binding affinity value compared to Favipiravir, namely -4.75 kcal/mol with a Ki value of 96.41 μM and has the same interaction as the positive control ligand on the hydrophobic bond of MET A:165
References
Aripin, I. (2019). Pendidikan nilai pada materi konsep sistem imun. Bio Educatio, 4(1), 377842.
Budiarto, H., & Rini, D. A. S. (2019). Fortifikasi Garam Dengan Bawang Dayak Untuk Meningkatkan Nutrisi Garam Konsumsi. Jurnal Kelautan: Indonesian Journal of Marine Science and Technology, 12(2), 104-111.
Fatiya, N. U., Kusnadi, I. F., Riyaldi, M. R., Dipadharma, R. H. F., Suhandi, C., Hidayat, S., & Muchtaridi, M. (2022). Studi in-silico Senyawa pada bawang putih (Allium sativum l.) Sebagai inhibitor neuraminidase pada influenza. Farmaka, 20(3), 1-11.
Febrinda, A., Yuliana, N., Ridwan, E., Wresdiyati, T., & Astawan, M. (2014). Hyperglycemic control and diabetes complication preventive activities of Bawang Dayak (Eleutherine palmifolia L. Merr.) bulbs extracts in alloxan-diabetic rats. International Food Research Journal, 21(4).
Fransira, I., Anggreini, A. F., Yanuhar, U., & Maftuch, M. (2019). Antibacterial activity of dayak onion bulbs (Eleutherine palmifolia (L) Merr) ethanol fraction against pseudomonas fluorescens and its secondary metabolite analysis. Research Journal of Life Science, 6(2), 94-103.
Frimayanti, N., Lukman, A., & Nathania, L. (2021). Studi molecular docking senyawa 1, 5-benzothiazepine sebagai inhibitor dengue DEN-2 NS2B/NS3 serine protease. Chempublish Journal, 6(1), 54-62.
Gholam, G. M., & Firdausy, I. A. (2022). Molecular docking study of natural compounds from red betel (Piper crocatum Ruiz & Pav) as inhibitor of secreted aspartic proteinase 5 (Sap 5) in Candida albicans. Sasambo Journal of Pharmacy, 3(2), 97-104.
Gowtham, S., Latha, S., & Kumar, M. S. (2022). Over view on molecular docking: a powerful approach for structure based drug discovery. Int. J. Pharm. Sci. Rev. Res, 77(29), 180-198.
Gymnastiar, A. P., Damayanti, D. S., & Tilaqza, A. (2024). STUDI IN SILICO POTENSI ANTIHIPERTENSI SENYAWA FITOKIMIA DAUN PEPAYA (Carica papaya) TERHADAP ANGIOTENSIN CONVERTING ENZYME DAN RESEPTOR ANGIOTENSIN II. Jurnal Kedokteran Komunitas (Journal of Community Medicine), 12(1).
Hasan, H., Thomas, N. A., Hiola, F., Ramadhani, F. N., & Ibrahim, A. S. (2022). Skrining fitokimia dan uji aktivitas antioksidan kulit batang matoa (Pometia pinnata) dengan metode 1, 1-diphenyl-2 picrylhidrazyl (DPPH). Indonesian Journal of Pharmaceutical Education, 2(1), 67-73.
Hussain, A., Bhowmik, B., & do Vale Moreira, N. C. (2020). COVID-19 and diabetes: Knowledge in progress. Diabetes research and clinical practice, 162, 108142.
Jakhar, R., Dangi, M., Khichi, A., & Chhillar, A. K. (2020). Relevance of molecular docking studies in drug designing. Current Bioinformatics, 15(4), 270-278.
Laby, J. R. A., Rumiati, F., & Sumbayak, E. M. (2017). Pengaruh Pemberian Bawang Dayak (Eleutherine palmifolia) terhadap Kadar Enzim Alanin Transaminase (ALT) dan Aspartat Transaminase (AST) Mencit yang Diinduksi Karbon Tetraklorida (CCl4). Jurnal Kedokteran Meditek.
Mutiah, R., Bhagawan, W. S., Ma'arif, B., & Rahmandika, J. M. S. (2019). Metabolite Fingerprinting Eleutherine palmifolia (L.) Merr. Using UPLC-QTOF-MS/MS. Majalah Obat Tradisional, 24(3), 139-159.
Ningrat, A. W. S. (2022). Docking Molekuler Senyawa Brazilein Herba Caesalpina Sappanis Lignum Pada Mycobacterium Tuberculosis Inha Sebagai Antituberkulosis. Indonesian Health Journal, 1(1), 29-34.
Sari, I. W., Junaidin, J., & Pratiwi, D. (2020). Studi Molecular Docking Senyawa Flavonoid Herba Kumis Kucing (Orthosiphon Stamineus B.) Pada Reseptor Α-Glukosidase Sebagai Antidiabetes Tipe 2. Jurnal Farmagazine, 7(2), 54-60.
Singh, N., Tang, Y., Zhang, Z., & Zheng, C. (2020). COVID-19 waste management: effective and successful measures in Wuhan, China. Resources, conservation, and recycling, 163, 105071.
Siregar, R. S., Hadiguna, R. A., Kamil, I., Nazir, N., & Nofialdi, N. (2020). Permintaan dan penawaran tanaman obat tradisional di provinsi sumatera utara. Jurnal Tumbuhan Obat Indonesia, 13(1), 50-60.
Syahrir, A., Rahem, A., & Prayoga, A. (2020). Religiositas mahasiswa farmasi UIN Malang selama pandemi COVID-19. Journal of Halal Product and Research, 3(1), 25-34.
Widyananda, M. H., Pratama, S. K., Samoedra, R. S., Sari, F. N., Kharisma, V. D., Ansori, A. N. M., & Antonius, Y. (2021). Molecular docking study of sea urchin (Arbacia lixula) peptides as multi-target inhibitor for non-small cell lung cancer (NSCLC) associated proteins. J Pharm Pharmacogn Res, 9(4), 484-496.
Yuliana, A., Fitriaji, H. S., Mukhaufillah, K. S., & Rizkuloh, L. R. (2020). In silico study on testing antidiabetic compounds candidate from azaphilone monascus sp.
Zhou, P., Liu, Z., Chen, Y., Xiao, Y., Huang, X., & Fan, X.-G. (2020). Bacterial and fungal infections in COVID-19 patients: a matter of concern. Infection Control & Hospital Epidemiology, 41(9), 1124-1125.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Lindawati Setyaningrum, Ulfa Dwi Septiana, Septyaningtyas Eka Wulandari, Nabila Kamalia, Tiara Anjelina Hezni, Mohammad Rofik Usman
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
